Day One

7:50 am Check In & Morning Coffee

8:50 am Chair’s Opening Remarks

Manmohan Singh

Chief Technology Officer, Beam Therapeutics

Turbocharging mRNA Innovation & Clinical Strategy to Advance the Future of Vaccines & Therapeutics for Patients Faster

9:00 am CEO Think Tank: Unlocking the Next Wave of mRNA-Based Vaccines, Therapeutics & Platforms to Develop Better mRNA Drugs Towards Clinical Reality

Joseph Payne

President & Chief Executive Officer, Arcturus Therapeutics

Priya Mande

Chief Executive Officer, RNAvate

Sophia Lugo

Chief Executive Officer, Chairman & Co-Founder, Radar Therapeutics

Manmohan Singh

Chief Technology Officer, Beam Therapeutics

Alexander Zehnder

Chief Executive Officer, CureVac

Ron Philip

Chief Executive Officer & Director, Orbital Therapeutics

Nathaniel Wang

Chief Executive Officer & Co-Founder, Replicate Bioscience

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10:00 am Panel Discussion: Harnessing the Potential of mRNA & Circular RNA Technology as a Tool to Advance In Vivo Engineering Cell & CAR-T Therapy

Gilles Besin

Chief Scientific Officer, Orbital Therapeutics

Nikola Ivica

Co founder - Head of Discovery, InnDura Therapeutics

Xian Zeng

Co-Founder & Board Member, Byterna Therapeutics

Trevor Hallam

Chief Scientific Officer, Sail Biomedicines

Joe Bolen

Chief Executive Officer, Orna Therapeutics

Thimmaiah Chendrimada

Founder, Able Sciences

Haig Aghajanian

Co-Founder and VP/Head of Research, Capstan Therapeutics

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11:00 am Morning Break & Speed Networking

Discovery Pre-Clinical Development Clinical Manufacturing & CMC

Discovery

Optimizing Novel mRNA-LNP Design & Platform Strategies to Accelerate Discovery Timelines – Chair

George Thom

Director & Team Leader - mRNA, AstraZeneca

John Zuris

Senior Director – Delivery & Technologies, Editas Medicine

11:30 am Circular RNA: From Promise to Reality

Priya Mande

Chief Executive Officer, RNAvate

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12:00 pm RNA Quality Control: A Sequencing-First Perspective

Wayne Doyle

Associate Director & Head of Platform, Eclipse Bio

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12:30 pm Recent Progress in mRNA-Based Targeted Protein Degrader Development

Jaehyun Choi

Executive Vice President & Head f Research & Development, Genexine

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Pre-Clinical Development

Optimizing Bioanalytical Strategies & Key In Vitro to In Vivo Data Towards Practical Applications of mRNA Vaccines & Therapeutics – Chair

Thimmaiah Chendrimada

Founder, Able Sciences

12:00 pm Bioanalytical Strategies for Advancing mRNA Therapeutics

Shyam Gudey

Principal Scientist, Moderna

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12:30 pm Tumor Suppression With mRNA-Encoded Ubiquitin-Specific Protease 6 (USP6) in Broad Pediatric & Adult Cancer Indications

Randall N. Hyer

Chief Executive Officer, Merlin Biotech

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Clinical

Advancing mRNA-Based Medicines From Pre-Clinical Development to Early Phase Trials to Effectively Treat Cancer

12:00 pm INTENT Lipid Nanoparticles for Cancer Vaccines

Natalia Martin-Orozco

Chief Scientific Officer, Providence Therapeutics

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12:30 pm Unlocking Recent Clinical Progress of mRNA-Based Vaccines & T-cell Engagers

Bo Ying

Chief Executive Officer, Abogen Biosciences

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Manufacturing & CMC

Scaling mRNA Cancer Vaccine Production & Processes With Automation Towards Better Efficiency & Speed – Chair

Kui Wang

Director of mRNA Sciences & Editing Technology Development, Verve Therapeutics

12:00 pm The mRNA Printer® – A Highly Automated Solution for Agile & Fast Manufacturing of Small-Scale Personalised Therapies

Markus Bergmann

Vice President, CureVac

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12:30 pm mRNA Manufacturing for BioNTech’s Individualized Neoantigen Specific Immunotherapies Against Cancer

Andreas Kuhn

Senior Vice President - Ribonucleic Acid Biochemistry & Chemistry Manufacturing Controls Development, BioNTech

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1:00 pm Lunch & Networking Break

Discovery Pre-Clinical Development Clinical Manufacturing & CMC

Discovery

Discovering Novel mRNA Vaccine & Therapeutic Proof-of-Concepts to Shine Light on Promising New Applications Across Disease Indications – Chair

George Thom

Director & Team Leader - mRNA, AstraZeneca

2:00 pm Selective Agonism of Specific Pattern Recognition Receptors to Generate Next Generation Novel Safe & Effective mRNA Vaccines & Therapeutics

Ajay Gupta

President, Chairman & Chief Executive Officer, Celestial Therapeutics

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2:30 pm mRNA Lipid Nanoparticles for the Treatment of Obesity

Thomas Lyle-Temple

Chief Executive Officer, Grann Pharmaceuticals

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Pre-Clinical Development

Unlocking Circular RNA Strategies for In Vivo Cell Reprogramming & Treatment of Autoimmune Diseases – Chair

Thimmaiah Chendrimada

Founder, Able Sciences

2:00 pm Unlocking Circular RNA to Treat Autoimmune Diseases

Gilles Besin

Chief Scientific Officer, Orbital Therapeutics

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2:30 pm In Vivo Reversible Programming of T Cells With SAIL’s Targeted NP-eRNA Platform for the Treatment of Autoimmune Diseases & Beyond

Trevor Hallam

Chief Scientific Officer, Sail Biomedicines

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Clinical

Advancing Clinical Development of Personalized & Off- The-Shelf mRNA Cancer Vaccines Towards Effective & Patient Specific Treatments

2:00 pm Unleashing Innovac’s Personalized Cancer Vaccine Platform (InnoPCV) for Clinical Trials

Nicholas Valiante

Chief Scientific Officer, Innovac Therapeutics

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2:30 pm Innovative Cancer Vaccine Platform: Advancing IE Technology for Targeted Cancer Therapies

Xiangrong Song

Chief Executive Officer & Co-Founder, WestGene Biopharma

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Manufacturing & CMC

Optimizing mRNA Analytics & Process Strategies to Better Characterize mRNA Drug Substance & Products – Chair

Kui Wang

Director of mRNA Sciences & Editing Technology Development, Verve Therapeutics

2:00 pm Emerging Techniques in Double-Stranded RNA Detection & Characterization

Mark Chipley

Principal Scientist, Pfizer

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2:30 pm Challenges to Breakthroughs: The Evaluation of mRNA Analytical Characterization & Control Strategy

Jianmei Kochling

Senior Director & Head Of Analytical Development Chemistry Manufacturing Controls & mRNA Center of Excellence, Vaccine Research, Sanofi

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3:00 pm Afternoon Break & Poster Session

Discovery Pre-Clinical Development Clinical Manufacturing & CMC

Discovery

Accelerating Novel Target Discovery for Targeted mRNA Therapeutics to Widen mRNA Application – Chair

George Thom

Director & Team Leader - mRNA, AstraZeneca

4:00 pm Exosome Inhibitors of Cardiac Apoptosis Induced by STEMIN & YAP5SA ModeRNA, the Next Breakthrough in Treating Heart Failure

Robert Schwartz

Chief Scientific Officer, Animatus Biosciences

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4:30 pm Targeted mRNA Therapeutics

Hamideh Parhiz

Assistant Professor- Pharmacology, University of Pennsylvania

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Pre-Clinical Development

Harnessing RNA-LNP Strategies for In Vivo Cell Reprogramming & Treatment of Autoimmune & Oncological Diseases – Chair

Thimmaiah Chendrimada

Founder, Able Sciences

3:30 pm Showcasing Orna Therapeutics’ PanCARTM Programs

Joe Bolen

Chief Executive Officer, Orna Therapeutics

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4:00 pm mRNA design, Nanoparticle Formulation & Revolutionary GMP, Microfluidic, Biochip-Based, Precision Manufacturing on the NMU-SymphonyTM – For Personalized Cancer Therapeutics & In Vivo Cell Therapy Applications

Ole Haabeth

Senior Director, Nutcracker Therapeutics

Session Details TBC

4:30 pm In Vivo CAR-T for Autoimmune Disease

Haig Aghajanian

Co-Founder and VP/Head of Research, Capstan Therapeutics

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Clinical

Early Breaking Clinical Case Studies Enabling Novel Routes of Administration to Maximize Efficiency of mRNA Therapeutics

4:00 pm Development of ETH47 as a Locally Administered mRNA Therapeutic For the Prevention of Asthma Exacerbations

Thomas Langenickel

Chief Medical Officer, Ethris

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4:30 pm Roundtable Discussion: Taking Advantage of Administration Routes for Enabling Successful Extra Hepatic Delivery to Widen the Landscape of Treatable Targets

Sean Bedingfield

Senior Advisor - Genetic Medicine, Eli Lilly

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Manufacturing & CMC

Developing a Robust & Scalable CMC Platform to Ensure Quality Manufacturing mRNA-Based Therapeutics & Vaccines Globally – Chair

Kui Wang

Director of mRNA Sciences & Editing Technology Development, Verve Therapeutics

3:30 pm Setting Up a Robust Platform for Scalable RNA Production on Demand & in Large Quantities

Diana Posadas

Director of Strategic Research, GreenLight BioSciences

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4:00 pm The Usage of CAP5011 & CAP1811 in mRNA Vaccines & Cancer Immunotherapies

May Guo

Chief Commercial Officer, Areterna

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4:30 pm Sustainable & Equitable Access to mRNA Technology: Update from Afrigen Biologics

Amin Khan

Chief Scientific Advisor, Afrigen Biologics

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Day One

Explore the Agenda

7:50 am Check In & Morning Coffee

8:50 am Chair’s Opening Remarks

Turbocharging mRNA Innovation & Clinical Strategy to Advance the Future of Vaccines & Therapeutics for Patients Faster

9:00 am CEO Think Tank: Unlocking the Next Wave of mRNA-Based Vaccines, Therapeutics & Platforms to Develop Better mRNA Drugs Towards Clinical Reality

10:00 am Panel Discussion: Harnessing the Potential of mRNA & Circular RNA Technology as a Tool to Advance In Vivo Engineering Cell & CAR-T Therapy

11:00 am Morning Break & Speed Networking

Optimizing Novel mRNA-LNP Design & Platform Strategies to Accelerate Discovery Timelines – Chair

11:30 am Circular RNA: From Promise to Reality

12:00 pm RNA Quality Control: A Sequencing-First Perspective

12:30 pm Recent Progress in mRNA-Based Targeted Protein Degrader Development

1:00 pm Lunch & Networking Break

Discovering Novel mRNA Vaccine & Therapeutic Proof-of-Concepts to Shine Light on Promising New Applications Across Disease Indications – Chair

2:00 pm Selective Agonism of Specific Pattern Recognition Receptors to Generate Next Generation Novel Safe & Effective mRNA Vaccines & Therapeutics

2:30 pm mRNA Lipid Nanoparticles for the Treatment of Obesity

3:00 pm Afternoon Break & Poster Session

Accelerating Novel Target Discovery for Targeted mRNA Therapeutics to Widen mRNA Application – Chair

4:00 pm Exosome Inhibitors of Cardiac Apoptosis Induced by STEMIN & YAP5SA ModeRNA, the Next Breakthrough in Treating Heart Failure

4:30 pm Targeted mRNA Therapeutics

5:00 pm End of Conference Day One

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