Day One

7:50 am Check In & Morning Coffee

8:50 am Chair’s Opening Remarks

Manmohan Singh

Chief Technology Officer, Beam Therapeutics

Turbocharging mRNA Innovation & Clinical Strategy to Advance the Future of Vaccines & Therapeutics for Patients Faster

9:00 am CEO Think Tank: Unlocking the Next Wave of mRNA-Based Vaccines, Therapeutics & Platforms to Develop Better mRNA Drugs Towards Clinical Reality

Joseph Payne

President & CEO, Arcturus Therapeutics

Priya Mande

Chief Scientific Officer, RNAvate

Sophia Lugo

Chief Executive Officer, Radar Therapeutics

Manmohan Singh

Chief Technology Officer, Beam Therapeutics

Alexander Zehnder

Chief Executive Officer, CureVac

Ron Philip

President and Chief Executive Officer, Orbital Therapeutics

Nathaniel Wang

Chief Executive Officer, Replicate Bioscience

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10:00 am Panel Discussion: Harnessing the Potential of mRNA & Circular RNA Technology as a Tool to Advance In Vivo Engineering Cell & CAR-T Therapy

Gilles Besin

Chief Scientific Officer, Orbital Therapeutics

Nikola Ivica

Co founder - Head of Discovery, InnDura Therapeutics

Xian Zeng

Co-Founder & CEO, Byterna Therapeutics

Trevor J Hallam

Chief Scientific Officer, Sail Biomedicines

Joe Bolen

Chief Executive Officer, Orna Therapeutics

Thimmaiah Chendrimada

Founder, Able Sciences

Haig Aghajanian

Co-Founder and VP/Head of Research, Capstan Therapeutics

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11:00 am Morning Break & Speed Networking

Discovery Pre-Clinical Development Clinical Manufacturing & CMC

Discovery

Optimizing Novel mRNA-LNP Design & Platform Strategies to Accelerate Discovery Timelines – Chair

George Thom

Director, AstraZeneca

John Zuris

Director, Editas Medicine

11:30 am Circular RNA: From Promise to Reality

Priya Mande

Chief Scientific Officer, RNAvate

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12:00 pm RNA Quality Control: A Sequencing-First Perspective

Wayne Doyle

Head Associate Director, Platform, Eclipse Bio

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12:30 pm Recent Progress in mRNA-Based Targeted Protein Degrader Development

Jaehyun Choi

Chief Executive Officer (Research & Development), Genexine

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Pre-Clinical Development

Optimizing Bioanalytical Strategies & Key In Vitro to In Vivo Data Towards Practical Applications of mRNA Vaccines & Therapeutics – Chair

Thimmaiah Chendrimada

Founder, Able Sciences

12:00 pm Bioanalytical Strategies for Advancing mRNA Therapeutics

Shyam Kumar Gudey

Principal Scientist, Moderna

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12:30 pm Tumor Suppression With mRNA-Encoded Ubiquitin-Specific Protease 6 (USP6) in Broad Pediatric & Adult Cancer Indications

Randall Hyer

Chief Executive Officer, Merlin Biotech

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Clinical

Advancing mRNA-Based Medicines From Pre-Clinical Development to Early Phase Trials to Effectively Treat Cancer

12:00 pm INTENT Lipid Nanoparticles for Cancer Vaccines

Natalia Martin Orozco

Chief Scientific Officer, Providence Therapeutics

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12:30 pm Unlocking Recent Clinical Progress of mRNA-Based Vaccines & T-cell Engagers

Bo Ying

Founder, Chairman & CEO, Abogen Biosciences

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Manufacturing & CMC

Scaling mRNA Cancer Vaccine Production & Processes With Automation Towards Better Efficiency & Speed – Chair

Kui Wang

Director, Verve Therapeutics

12:00 pm The mRNA Printer® – A Highly Automated Solution for Agile & Fast Manufacturing of Small-Scale Personalised Therapies

Markus Bergmann

Vice President, CureVac

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12:30 pm mRNA Manufacturing for BioNTech’s Individualized Neoantigen Specific Immunotherapies Against Cancer

Andreas Kuhn

Senior Vice President - Ribonucleic Acid Biochemistry & Chemistry Manufacturing & Controls Development, BioNTech

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1:00 pm Lunch & Networking Break

Discovery Pre-Clinical Development Clinical Manufacturing & CMC

Discovery

Discovering Novel mRNA Vaccine & Therapeutic Proof-of-Concepts to Shine Light on Promising New Applications Across Disease Indications – Chair

George Thom

Director, AstraZeneca

2:00 pm Selective Agonism of Specific Pattern Recognition Receptors to Generate Next Generation Safe & Effective mRNA Vaccines & Therapeutics

Ajay Gupta

President, Chairman & Chief Executive Officer, Celestial Therapeutics

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2:30 pm mRNA Lipid Nanoparticles for the Treatment of Obesity

Thomas Lyle-Temple

Chief Executive Officer, Grann Pharmaceuticals

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Pre-Clinical Development

Unlocking Circular RNA Strategies for In Vivo Cell Reprogramming & Treatment of Autoimmune Diseases – Chair

Thimmaiah Chendrimada

Founder, Able Sciences

2:00 pm Unlocking Circular RNA to Treat Autoimmune Diseases

Gilles Besin

Chief Scientific Officer, Orbital Therapeutics

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2:30 pm In Vivo Reversible Programming of T Cells With SAIL’s Targeted NP-eRNA Platform for the Treatment of Autoimmune Diseases & Beyond

Trevor J Hallam

Chief Scientific Officer, Sail Biomedicines

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Clinical

Advancing Clinical Development of Personalized & Off- The-Shelf mRNA Cancer Vaccines Towards Effective & Patient Specific Treatments

2:00 pm Unleashing Innovac’s Personalized Cancer Vaccine Platform (InnoPCV) for Clinical Trials

Nick Valiante

Co-Founder and CSO, Innovac Therapeutics

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2:30 pm Innovative Cancer Vaccine Platform: Advancing IE Technology for Targeted Cancer Therapies

Xiangrong Song

CEO & Co-founder, WestGene Biopharma

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Manufacturing & CMC

1:45 pm Guide To Lean Manufacturing: Redefining The Concept of mRNA Development

Scott Alderucci

Director, Process Development, Curia

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Optimizing mRNA Analytics & Process Strategies to Better Characterize mRNA Drug Substance & Products – Chair

Kui Wang

Director, Verve Therapeutics

2:00 pm Emerging Techniques in Double-Stranded RNA Detection & Characterization

Mark Chipley

Principal Scientist, Pfizer

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2:30 pm Challenges to Breakthroughs: The Evaluation of mRNA Analytical Characterization & Control Strategy

Jianmei Kochling

Senior Director & Head Of Analytical Development Chemistry Manufacturing Controls & mRNA Center of Excellence, Vaccine Research, Sanofi

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3:00 pm Afternoon Break & Poster Session

Discovery Pre-Clinical Development Clinical Manufacturing & CMC

Discovery

Accelerating Novel Target Discovery for Targeted mRNA Therapeutics to Widen mRNA Application – Chair

George Thom

Director, AstraZeneca

4:00 pm Exosome Inhibitors of Cardiac Apoptosis Induced by STEMIN & YAP5SA ModeRNA, the Next Breakthrough in Treating Heart Failure

Robert Schwartz

Chief Scientific Officer, Animatus Biosciences

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4:30 pm Targeted mRNA Therapeutics

Hamideh Parhiz

Assistant Professor- Pharmacology, University of Pennsylvania

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Pre-Clinical Development

Harnessing RNA-LNP Strategies for In Vivo Cell Reprogramming & Treatment of Autoimmune & Oncological Diseases – Chair

Thimmaiah Chendrimada

Founder, Able Sciences

3:30 pm Showcasing Orna Therapeutics’ PanCARTM Programs

Joe Bolen

Chief Executive Officer, Orna Therapeutics

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4:00 pm mRNA design, Nanoparticle Formulation & Revolutionary GMP, Microfluidic, Biochip-Based, Precision Manufacturing on the NMU-SymphonyTM – For Personalized Cancer Therapeutics & In Vivo Cell Therapy Applications

Ole Haabeth

Senior Director, Nutcracker Therapeutics

Session Details TBC

4:30 pm In Vivo CAR-T for Autoimmune Disease

Haig Aghajanian

Co-Founder and VP/Head of Research, Capstan Therapeutics

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Clinical

Early Breaking Clinical Case Studies Enabling Novel Routes of Administration to Maximize Efficiency of mRNA Therapeutics

4:00 pm Development of ETH47 as a Locally Administered mRNA Therapeutic For the Prevention of Asthma Exacerbations

Thomas Langenickel

Chief Medical Officer, Ethris

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4:30 pm Roundtable Discussion: Taking Advantage of Administration Routes for Enabling Successful Extra Hepatic Delivery to Widen the Landscape of Treatable Targets

Sean Bedingfield

Senior Advisor - Genetic Medicine, Eli Lilly

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Manufacturing & CMC

Developing a Robust & Scalable CMC Platform to Ensure Quality Manufacturing mRNA-Based Therapeutics & Vaccines Globally – Chair

Kui Wang

Director, Verve Therapeutics

3:30 pm Setting Up a Robust Platform for Scalable RNA Production on Demand & in Large Quantities

Diana M Posadas

Downstream Process Development Scientist II, GreenLight BioSciences

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4:00 pm The Usage of CAP5011 & CAP1811 in mRNA Vaccines & Cancer Immunotherapies

May Guo

Chief Commercial Officer, Areterna

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4:30 pm Sustainable & Equitable Access to mRNA Technology: Update from Afrigen Biologics

Amin Khan

Chief Scientific Advisor, Afrigen Biologics

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Day One

Explore the Agenda

7:50 am Check In & Morning Coffee

8:50 am Chair’s Opening Remarks

Turbocharging mRNA Innovation & Clinical Strategy to Advance the Future of Vaccines & Therapeutics for Patients Faster

9:00 am CEO Think Tank: Unlocking the Next Wave of mRNA-Based Vaccines, Therapeutics & Platforms to Develop Better mRNA Drugs Towards Clinical Reality

10:00 am Panel Discussion: Harnessing the Potential of mRNA & Circular RNA Technology as a Tool to Advance In Vivo Engineering Cell & CAR-T Therapy

11:00 am Morning Break & Speed Networking

Optimizing Novel mRNA-LNP Design & Platform Strategies to Accelerate Discovery Timelines – Chair

11:30 am Circular RNA: From Promise to Reality

12:00 pm RNA Quality Control: A Sequencing-First Perspective

12:30 pm Recent Progress in mRNA-Based Targeted Protein Degrader Development

1:00 pm Lunch & Networking Break

Discovering Novel mRNA Vaccine & Therapeutic Proof-of-Concepts to Shine Light on Promising New Applications Across Disease Indications – Chair

2:00 pm Selective Agonism of Specific Pattern Recognition Receptors to Generate Next Generation Safe & Effective mRNA Vaccines & Therapeutics

2:30 pm mRNA Lipid Nanoparticles for the Treatment of Obesity

3:00 pm Afternoon Break & Poster Session

Accelerating Novel Target Discovery for Targeted mRNA Therapeutics to Widen mRNA Application – Chair

4:00 pm Exosome Inhibitors of Cardiac Apoptosis Induced by STEMIN & YAP5SA ModeRNA, the Next Breakthrough in Treating Heart Failure

4:30 pm Targeted mRNA Therapeutics

5:00 pm End of Conference Day One

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