Mark Kidd
Laboratory Director Wren Laboratories
Seminars
Tuesday 21st July 2026
Decentralized PK/PD Bioanalysis for mRNA Therapeutics via Stabilized Whole-Blood RT-PCR
11:30 am
- Developing a whole-blood RNA analysis platform for sensitive and scalable bioanalysis of mRNA therapeutics
- Combining construct-specific RT-PCR assays with proprietary stabilization chemistry that preserves RNA at ambient temperature for up to 10 days, enabling decentralized sampling and global trial logistics.
- Quantifying target mRNA in blood with high sensitivity (~1–3 copies), supporting exploratory PKPD, and exposure–response analyses across serial timepoints.
- Minimizing pre-analytical variability to achieve low sample failure rates (<0.1%), enabling reliable longitudinal sampling
