David Thompson

David H. Thompson is a Professor of Organic Chemistry at Purdue University. His current research is focused on [1] the development of bioresponsive self-assembling materials for targeted delivery of nucleic acid therapeutics that merge supramolecular and organic reaction mechanism concepts, and [2] the continuous synthesis of active pharmaceutical ingredients using telescoped flow chemistry techniques. His earlier work with nucleic acid delivery using low pH-activated lipids (Pharm. Res. 2002), polyrotaxanes (Mol. Pharm. 2013), and degradable polymers (Macromolecules 2018) ultimately led to the development of a targeted layer-by-layer elastin-like polypeptide nucleic acid nanoparticle (LENN) system derived from biomanufacturable components that displays efficient delivery activity in vitro and in vivo.