Ali Nahvi
Chief Technology Officer Nava Therapeutics
Seminars
Tuesday 21st July 2026
In Vivo Generation of Functional CAR T Cells via Targeted Non-Viral Lipid Nanoparticles Enables Potent Immune Cell Depletion in Non-Human Primates
11:00 am
- Targeted lipid nanoparticle platform facilitates generation of transient CAR-T cells to allow rapid B cell depletion without lymphodepletion
- In non-human primates, delivery of an anti-CD20 CAR mRNA induced profound B cell depletion in blood and lymphoid tissues including spleen, bone marrow and lymph nodes
- Demonstrating excellent safety and tolerability, the off-the-shelf candidate allows B cells recovery to occur with predominately naïve phenotypes, supporting immune reset and translational potential for autoimmune diseases
