Stabilizer Elements are a Modular Linear mRNA Platform for Potent & Durable Therapeutic Protein Expression
- • Introducing Stabilizer Elements as a modular mRNA technology that provides potent and durable (i.e., circular RNAlike) therapeutic protein expression from linear mRNA
- Stabilizer Elements can be used to engineer mRNA in vivo CAR-T cell therapy with best-in-class ability to deplete peripheral and tissue-resident B cells
- The Stabilizer Element mRNA platform is a superior alternative to circular RNA due to its enhanced performance across diverse cellular contexts, simpler manufacturing, and compatibility with N1-methylpseudouridine