Harnessing Lariat-Capping to Improve the Stability & Therapeutic Efficacy of mRNA & Self-Amplifying RNA
- 5’ lariat-cap (LC) structure stabilizes mRNA
- Lariat-capped (LC) mRNAs and LC saRNAs show higher protein expression than a conventional clean‑capped counterparts
- Showcasing SARS‑CoV‑2 vaccines with LC saRNA induce strong neutralizing antibodies