Sruthi Santhanam
Principal Scientist Breeze Bio
Seminars
Wednesday 22nd July 2026
A Novel Hydrophilic Nanoparticle mRNA Platform for Antigen-Specific Immune Tolerance in Autoimmune Diseases
2:30 pm
- Introducing BreezeBio’s NanoGalaxy™, a fully synthetic, tunable, water-formulated hydrophilic polymer nanoparticle (HNP) platform that delivers mRNA-encoded antigens and small-molecule immunomodulators directly to splenic APCs with minimal off-target hepatic, renal, or CNS uptake
- Demonstrating antigen-specific T cell activation that translates from mice to non-human primates, alongside antigen-specific Treg induction and disease-modifying efficacy across multiple mouse models of autoimmunity
- Showcasing that antigen mRNA plus small-molecule/mRNA co-payloads durably delay and prevent autoimmune diabetes onset in prophylactic and therapeutic NOD models of type 1 diabetes
