Deep Learning Guided Optimization of Translation Efficiency for mRNA Vaccine Development

• Delivered mRNA vaccines benefit from a high protein yield to stimulate an effective immune response
• Training RiboNN, a deep learning model, to predict translation efficiency — a major determinant of protein yield — among numerous cell types
• RiboNN can be used to guide the design of translation-optimized mRNA therapeutics

Speakers:

Vikram Agarwal

mRNA Platform Design Data Science Head

mRNA Center of Excellence, Sanofi