Impact of mRNA Design on In Vivo Murine mRNA-LNP CD19 CAR in a Syngeneic Mouse Model

• Syngeneic mouse models provide key advantages for preclinical evaluation of CAR‑T cell efficacy and biology
• Functional murine CAR scFv identification and preliminary data on mCD8‑targeted LNP delivery
• Optimization of murine CD19 CAR mRNA is required to further enhance performance