Novel Efficient Cap Analog & Rapid Eliminated Ionizable Lipid Improve the Efficacy & Safety of mRNA-Based Protein Replacement Therapy
- mRNAs with LZCap® exhibit superior pharmacokinetics profile in vivo studies across multiple species, including rats, beagle dogs, pigs, and cynomolgus monkeys
- Novel ionizable lipid-based LNPs achieve high transfection efficiency with rapid in vivo clearance and favorable safety profiles
- Preclinical studies of protein replacement pipelines demonstrate robust efficacy and excellent tolerability